A small clinical trial reported that CBD partially inhibited the CYP2C-catalyzed hydroxylation of THC to 11-OH-THC. Little is known about potential drug interactions, but CBD mediates a decrease in clobazam metabolism. Research indicates that cannabidiol may reduce adverse effects of THC, particularly those causing intoxication and sedation, but only at high doses.
Safety studies of cannabidiol showed it is well tolerated, but may cause tiredness, diarrhea, or changes in appetite as common adverse effects. Epidiolex documentation lists sleepiness, insomnia and poor quality sleep, decreased appetite, diarrhea, and fatigue. As of 2019, there was only limited high-quality evidence for cannabidiol having a neurological effect in people, mainly due CBD oil for humans to the weak design and small number of subjects in randomized controlled trials. For example, epilepsy studies found that "there were very clearly increases in the blood levels of some other anti-epileptic drugs when people were on CBD," Welty said.
Laboratory evidence indicated that cannabidiol may reduce THC clearance, increasing plasma concentrations which may raise THC availability to receptors and enhance its effect in a dose-dependent manner. In vitro, cannabidiol inhibited the activity of voltage-dependent sodium and potassium channels, which may affect neural activity.
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- As a renewable source of a range of products, hemp provides an exciting new step in American agriculture.
- This high-CBD hemp oil is legal at the federal level in the U.S. like any other commercial hemp product and can be sold and delivered in the United States.
- The size of this import industry was one of the major catalysts for hemp legalization in the U.S.
- Therefore, the hemp used to create many of the high CBD products available in America is cultivated in various countries around the world, mainly in Europe.
- CBD is not psychoactive, nor will it cause you to experience any euphoric effects.
Research on the use of cannabidiol for psychotic symptoms in people with schizophrenia is conflicting. Some early research suggests that taking cannabidiol four times daily for 4 weeks improves psychotic symptoms and might be as effective as the antipsychotic medication amisulpride. However, other early research suggests that taking cannabidiol for 14 days is not beneficial.
The conflicting results might be related to the cannabidiol dose used and duration of treatment. Early research suggests that taking 160 mg of cannabidiol before bed improves sleep time in people with insomnia.
Nearly 43 percent of the products contained too little CBD, while about 26 percent contained too much, Bonn-Miller said. There also are concerns about both the quality of CBD oil being produced and its potential side effects, the experts added. CBD oil is legal in 30 states where medicinal and/or recreational marijuana is legal, according to Governing magazine. Some reported side effects of cannabidiol include dry mouth, low blood pressure, light headedness, and drowsiness. Signs of liver injury have also been reported in some patients, but this is less common.
Cannabidiol also does not seem to help people fall asleep and might reduce the ability to recall dreams. An inherited condition marked by learning disabilities (fragile- X syndrome).
Early research found that applying cannabidiol gel might reduce anxiety and improve behavior in patients with fragile X syndrome. A movement disorder marked by involuntary muscle contractions . Early research suggests that taking cannabidiol daily for 6 weeks might improve dystonia by 20% to 50% in some people.